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intracellular innate immune receptors

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In this issue of Immunological Reviews, we explore the intracellular innate immune receptors, characterizing their sensing and signaling pathways and detailing their diverse roles in health and disease.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2020Immunological ReviewsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1class membershipsupports2020Source 1DOI PubMed

NLRP1, NLRP3, NLRC4, AIM2, and pyrin are described as well-characterized intracellular receptors that form inflammasomes, whereas NLRC1 and NLRC2 are described as NLR family members that do not.

Claim 2mechanism summarysupports2020Source 1DOI PubMed

AIM2 is described as a nucleic acid sensor that responds to diverse pathogens, and IRF1-induced GBPs and IRGB10 can rupture bacteria to release ligands sensed by AIM2 and the noncanonical NLRP3 inflammasome.

Claim 3mechanism summarysupports2020Source 1DOI PubMed

Some intracellular pattern recognition receptors form inflammasomes that activate caspase-1, process IL-1β and IL-18, and drive pyroptotic cell death.

Claim 4mechanism summarysupports2020Source 1DOI PubMed

ZBP1 is described as the innate immune sensor that triggers NLRP3 activation during influenza A virus infection through sensing Z-nucleic acids, and deletion of the Zα2 sensing domain abolishes this NLRP3 activation response.