K+-selective channelrhodopsins (KCRs) have emerged as attractive alternatives to chloride-conducting channels for optogenetic inhibition of cellular excitability, but many KCR variants exhibit an ion selectivity shift toward Na+ under prolonged illumination.
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K+-selective channelrhodopsins
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KCRs
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K+-selective channelrhodopsins are attractive alternatives to chloride-conducting channels for optogenetic inhibition of cellular excitability.
Quoted textsource-backed
K+-selective channelrhodopsins (KCRs) have emerged as attractive alternatives to chloride-conducting channels for optogenetic inhibition of cellular excitability
Stability of ion selectivity is a design criterion for next-generation optogenetic tools.
Quoted textsource-backed
These findings highlight the stability of ion selectivity as a design criterion and provide guidance for the design of next generation optogenetic tools
Many KCR variants shift ion selectivity toward Na+ under prolonged illumination, limiting their utility for silencing neural circuits.
Quoted textsource-backed
many KCR variants exhibit an ion selectivity shift toward Na+ under prolonged illumination... both the absolute K+ to Na+ permeability ratio and its stability over time determine the inhibition to activation transition, which limits their utility for silencing neural circuits
Both the absolute K+ to Na+ permeability ratio and its stability over time determine the inhibition-to-activation transition in KCRs.
Quoted textsource-backed
it is found that both the absolute K+ to Na+ permeability ratio and its stability over time determine the inhibition to activation transition