First-pass extracted concept

Keap1 C151-dependent Nrf2 derepression

Candidate: concept label1 source documents3 linked claims

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Aliases

C151 in Keap1 to derepress Nrf2, Keap1 C151 targeting

Evidence Snippets

Together, these findings demonstrate that Kyn-CKA targets C151 in Keap1 to derepress Nrf2

Evidence 1Source 1DOIprovenance

Supporting Sources

Source 1primary paper2025PPRDOI

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1biochemical specificitysupports2025Source 1DOI

Kyn-CKA reacts with wild-type but not C151S mutant Keap1 BTB domain and reacts faster with wild-type Keap1 BTB than with N-acetyl cysteine.

Claim 2genotype dependencesupports2025Source 1DOI

Kyn-CKA increases Nrf2 abundance and NQO1 expression in MEFs expressing wild-type Keap1, but this inducer potency is greatly diminished in C151S-Keap1 mutant MEFs.

Claim 3mechanismsupports2025Source 1DOI

Kyn-CKA targets C151 in Keap1 to derepress Nrf2.