First-pass extracted concept

kinetic ruler mechanism

Candidate: concept label2 source documents5 linked claims

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Aliases

kinetic ruler

Evidence Snippets

As a result, poly(A) tail length control operates through a “kinetic ruler” mechanism, whereby the concentration of Nab2 quantifies RNA length.

Evidence 1Source 1DOIprovenance

As a result, poly(A) tail length control operates through a "kinetic ruler" mechanism, whereby the concentration of Nab2 quantifies RNA length.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025PPRDOI

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1mechanismsupports2025Source 1DOI

Mature poly(A) tail length is determined by kinetic competition between CPAC-mediated tail elongation and Nab2 RNA binding rather than by the Nab2 RNA footprint.

Claim 2mechanismsupports2025Source 2DOI PubMed

Mature poly(A) tail length is determined by kinetic competition between CPAC-mediated tail elongation and Nab2 RNA binding rather than by the Nab2 RNA footprint.

Claim 3mechanismsupports2025Source 2DOI PubMed

Poly(A) tail length control operates through a kinetic ruler mechanism in which Nab2 concentration quantifies RNA length.

Claim 4mechanismsupports2025Source 1DOI

Poly(A) tail length control operates through a kinetic ruler mechanism in which Nab2 concentration quantifies RNA length.

Claim 5mechanismsupports2025Source 1DOI

Variations in Nab2 RNA-binding rate can shift poly(A) tail lengths, but in cells these effects are buffered by autoregulation of Nab2 protein concentration.