Here, we demonstrate that inwardly rectifying potassium channels, particularly Kir7.1 (Kcnj13), maintain the resting membrane potential and are crucial for directional sensing during neutrophil chemotaxis.
First-pass extracted concept
Kir7.1 (Kcnj13)
Candidate: concept label1 source documents4 linked claims
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Aliases
Kcnj13, Kir7.1
Evidence Snippets
Supporting Sources
Linked Claims
Genetically encoded voltage indicators revealed oscillating hyperpolarization during tail retraction in zebrafish neutrophils, and Kir7.1 was required for depolarization toward the chemokine source.
Quoted textsource-backed
Using genetically encoded voltage indicators, we observed oscillating hyperpolarization during tail retraction in zebrafish neutrophils, with Kir7.1 required for depolarization toward the chemokine source.
Inwardly rectifying potassium channels, particularly Kir7.1 (Kcnj13), maintain resting membrane potential and are crucial for directional sensing during neutrophil chemotaxis.
Quoted textsource-backed
Here, we demonstrate that inwardly rectifying potassium channels, particularly Kir7.1 (Kcnj13), maintain the resting membrane potential and are crucial for directional sensing during neutrophil chemotaxis.
Blocking or knocking out inwardly rectifying potassium channels in neutrophils disrupts directional sensing toward different chemoattractants in multiple models.
Quoted textsource-backed
Blocking or knocking out Kir in neutrophils disrupted their ability to sense direction toward different chemoattractants in multiple models.
Inwardly rectifying potassium channels influence GPCR signaling activation in dHL-60 cells.
Quoted textsource-backed
Additionally, Kir influences GPCR signaling activation in dHL-60 cells.