First-pass extracted concept

Kiss1r

Candidate: concept label2 source documents5 linked claims

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Aliases

kisspeptin receptor

Extracted Explainers

What the tool is doing

KISS1R is the receptor through which kisspeptin activates signaling that promotes GnRH secretion. The review treats the kisspeptin/KISS1R system as central to HPG-axis control.

Source 1DOI PubMed

What problem it solves

It explains the receptor-level mechanism connecting kisspeptin to reproductive endocrine output. The abstract also links disorders of this system to reproductive disease.

Source 1DOI PubMed

What it does not solve

The abstract does not specify receptor-targeting methods, constructs, or assays. It therefore does not support extraction as a discrete toolkit item.

Source 1DOI PubMed

Alternatives

No direct receptor alternative is named in the abstract, though adjacent KNDy-neuron components neurokinin B and dynorphin are discussed in the same regulatory network.

Source 1DOI PubMed

Evidence Snippets

Kisspeptin activates the signaling pathway by binding to its receptor kisspeptin receptor (KISS1R) to promote GnRH secretion.

Evidence 1Source 1DOI PubMedprovenance

These neurons project to and activate gonadotrophin-releasing hormone (GnRH) neurons (acting via the kisspeptin receptor, Kiss1r) in the hypothalamus and stimulate the secretion of GnRH.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2022Frontiers in EndocrinologyDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2018Journal of EndocrinologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2022Source 1DOI PubMed

Mutations in KISS1 or disorders of the kisspeptin/KISS1R system may lead to idiopathic hypogonadotropic hypogonadism, central precocious puberty, and female infertility.

Quoted textsource-backed

Mutations in the KISS1 gene or disorders of the kisspeptin/KISS1R system may lead to clinical symptoms such as idiopathic hypogonadotropic hypogonadism (iHH), central precocious puberty (CPP) and female infertility.

Claim 2mechanistic rolesupports2022Source 1DOI PubMed

Kisspeptin is a critical central regulatory factor of GnRH release and acts through KISS1R to promote GnRH secretion, thereby regulating the HPG axis.

Quoted textsource-backed

The discovery of kisspeptin as a critical central regulatory factor of GnRH release... Kisspeptin activates the signaling pathway by binding to its receptor kisspeptin receptor (KISS1R) to promote GnRH secretion, thereby regulating the hypothalamic-pituitary-gonadal axis (HPG) axis.

Claim 3expression summarymixed2018Source 2DOI PubMed

Kiss1r is expressed in adipose tissue and potentially brown adipose tissue, but the mechanisms underlying the metabolic observations remain unknown.

Claim 4mechanismsupports2018Source 2DOI PubMed

Kisspeptin neurons project to and activate GnRH neurons via Kiss1r to stimulate GnRH secretion.

Claim 5phenotype summarysupports2018Source 2DOI PubMed

Kiss1r knockout mice exhibit increased adiposity and reduced energy expenditure.