First-pass extracted concept

kisspeptin neurons

Candidate: concept label2 source documents6 linked claims

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Evidence Snippets

Female sexual behavior in mice is controlled by kisspeptin neurons

Kisspeptin is produced by two major populations of neurons located in the hypothalamus, the rostral periventricular region of the third ventricle (RP3V) and arcuate nucleus (ARC).

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2018Nature CommunicationsDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2review2018Journal of EndocrinologyDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1anatomical localizationsupports2018Source 2DOI PubMed

Kisspeptin is produced by two major hypothalamic neuron populations in the RP3V and ARC.

Claim 2feedback modelsupports2018Source 2DOI PubMed

Gonadal sex steroids stimulate RP3V kisspeptin neurons but inhibit ARC kisspeptin neurons, underlying positive and negative feedback respectively.

Claim 3functional rolesupports2018Source 1DOI PubMed

Kisspeptin neurons control female sexual behavior in mice.

Claim 4mechanismsupports2018Source 2DOI PubMed

Kisspeptin neurons project to and activate GnRH neurons via Kiss1r to stimulate GnRH secretion.

Claim 5mechanistic modelsupports2018Source 2DOI PubMed

ARC kisspeptin neurons are commonly accepted to act as the GnRH pulse generator.

Claim 6physiology rolesupports2018Source 2DOI PubMed

Energy balance is an important afferent input area for kisspeptin neurons and may contribute to fertility suppression during undernutrition or severe overnutrition.