First-pass extracted concept

Kv1.3 channel regulation by α-Klotho

Candidate: concept label1 source documents3 linked claims

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Aliases

Kv1.3 regulation by recombinant human Klotho protein

Evidence Snippets

The present study explored the impact of alpha Klotho protein on the voltage gated K+ channel Kv1.3.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2014Kidney & Blood Pressure ResearchDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1cross system observationsupports2014Source 1DOI PubMed

Recombinant human Klotho protein increased Kv currents and Kv1.3 protein abundance in Jcam lymphoma cells.

Quoted textsource-backed

treatment with recombinant human Klotho protein increased Kv currents and Kv1.3 protein abundance in Jcam cells

Claim 2mechanism activity relationshipsupports2014Source 1DOI PubMed

Recombinant human Klotho protein enhances Kv1.3 channel abundance and Kv1.3 currents in the plasma membrane.

Quoted textsource-backed

Alpha Klotho protein enhances Kv1.3 channel abundance and Kv1.3 currents in the plasma membrane

Claim 3mechanistic dependencysupports2014Source 1DOI PubMed

The Klotho-dependent enhancement of Kv1.3 abundance and current depends on β-glucuronidase activity.

Quoted textsource-backed

an effect reversed by presence of DSAL. Moreover, treatment with recombinant human Klotho protein increased Kv currents and Kv1.3 protein abundance in Jcam cells. Conclusion Alpha Klotho protein enhances Kv1.3 channel abundance and Kv1.3 currents in the plasma membrane, an effect depending on its β-glucuronidase activity.