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L-lactate as an astrocytic signalling molecule

Candidate: concept label1 source documents6 linked claims
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Aliases

glio-transmitter

Extracted Explainers

What the tool is doing

The paper presents L-lactate as a signaling molecule released from astrocytes that excites locus coeruleus neurons and promotes norepinephrine release. The abstract explicitly distinguishes this role from lactate's caloric function.

Source 1DOIPubMed

What problem it solves

It addresses how astrocytes may directly signal to neurons in the locus coeruleus using lactate rather than only supplying metabolic substrate.

Source 1DOIPubMed

What it does not solve

The abstract does not identify the receptor responsible for the reported signaling effect.

Source 1DOIPubMed

Alternatives

The source contrasts signaling by L-lactate with its conventional role as an energy source for neurons.

Source 1DOIPubMed

Evidence Snippets

Here we present evidence that L-lactate, independently of its caloric value, serves as an astrocytic signalling molecule in the locus coeruleus (LC).
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1causal effectsupports2014Source 1DOIPubMed

Optogenetically activated astrocytes release L-lactate, which excites locus coeruleus neurons and triggers norepinephrine release.

Quoted textsource-backed
Optogenetically activated astrocytes release L-lactate, which excites LC neurons and triggers release of norepinephrine.
Claim 2functional equivalencesupports2014Source 1DOIPubMed

Exogenous L-lactate within the physiologically relevant concentration range mimics the excitatory effects of astrocyte-derived L-lactate on locus coeruleus neurons.

Quoted textsource-backed
Exogenous L-lactate within the physiologically relevant concentration range mimics these effects.
Claim 3hypothesissupports2014Source 1DOIPubMed

The results imply the existence of an unknown receptor mediating L-lactate glia-neuronal signaling.

Quoted textsource-backed
Our results imply the existence of an unknown receptor for this 'glio-transmitter'.
Claim 4in vivo effectsupports2014Source 1DOIPubMed

In vivo L-lactate injection into the locus coeruleus evokes arousal similar to L-glutamate.

Quoted textsource-backed
In vivo injections of L-lactate in the LC evokes arousal similar to the excitatory transmitter, L-glutamate.
Claim 5mechanismsupports2014Source 1DOIPubMed

L-lactate effects are concentration-dependent, stereo-selective, independent of neuronal L-lactate uptake, and involve a cAMP-mediated step.

Quoted textsource-backed
L-lactate effects are concentration-dependent, stereo-selective, independent of L-lactate uptake into neurons and involve a cAMP-mediated step.
Claim 6mechanismsupports2014Source 1DOIPubMed

L-lactate serves as an astrocytic signalling molecule in the locus coeruleus independently of its caloric value.

Quoted textsource-backed
Here we present evidence that L-lactate, independently of its caloric value, serves as an astrocytic signalling molecule in the locus coeruleus (LC).