The abstract describes lactate as both a metabolic substrate and a signaling molecule that modulates macrophage polarization.
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lactate
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recent evidence suggests that lactate plays dual roles in the nervous system: neuroprotective and neurotoxicity.
Lactate, the final product of glycolysis, is also pivotal in contributing to drug resistance in HCC.
Lactate generated by aerobic glycolysis is an essential substrate for the tricarboxylic acid cycle and for post-translational modifications via histone lactylation and epigenetic regulation. It also serves as a signaling molecule that modulates macrophage polarization between pro- and anti-inflammatory phenotypes.
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Linked Claims
Lactate has dual roles in the nervous system, including neuroprotective and neurotoxic effects.
Metabolic and signaling mechanisms interact synergistically to allow hepatocellular carcinoma cells to survive and proliferate despite targeted therapies, resulting in drug resistance.
Quoted textsource-backed
These mechanisms interact synergistically, allowing HCC cells to endure and proliferate despite targeted therapies, ultimately resulting in drug resistance.
Lactate contributes to drug resistance in hepatocellular carcinoma.
Quoted textsource-backed
Lactate, the final product of glycolysis, is also pivotal in contributing to drug resistance in HCC.
Lactate-related mechanisms in the nervous system involve energy metabolism, neurodegeneration, neural excitation, and neuroinflammation.
The functions of lactate in the nervous system are influenced by varying concentrations and distinct signal transduction pathways.
Pharmacological agents associated with lactate- and lactylation-related processes may inform therapeutic strategies for neuroprotection under hypoxia and for neurological disorders.
The roles of lactate and lactylation modification in sepsis remain unclear.
Lactate acts as a signaling molecule that modulates macrophage polarization between pro-inflammatory and anti-inflammatory phenotypes in response to local inflammatory and metabolic signals.
Lactate generated by aerobic glycolysis serves as a substrate for the tricarboxylic acid cycle and for histone lactylation-associated epigenetic regulation.
Regulation by lactate and lactylation during macrophage polarization in sepsis may represent a potential therapeutic target for sepsis.