We propose a conceptual framework, the "Lactylation-immunosuppression network," that links tumor metabolic reprogramming to immune cell signaling and gene expression.
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Lactylation-immunosuppression network
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The paper proposes a lactylation-immunosuppression network framework linking tumor metabolic reprogramming to immune cell signaling and gene expression.
The review states that lactylation may undermine anti-tumor immunity by remodeling myeloid and T cell compartments, fortifying immune checkpoint barriers, and creating self-reinforcing metabolic feedback loops.
The proposed metabolic-epigenetic axis links lactylation to immunosuppression through two synergistic mechanisms: histone lactylation for stable epigenetic programming and non-histone lactylation for rapid modulation of protein activity and stability.