First-pass extracted concept

lateral septum neurotensin neurons

Candidate: concept label1 source documents3 linked claims

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Aliases

NT^LS neurons, NTLS neurons

Evidence Snippets

we identified a population of stress/threat-responsive lateral septum neurotensin (NTLS) neurons that are activated by juvenile social interactions only in SUS mice

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2022NatureDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1causal modulationsupports2022Source 1DOI PubMed

Optogenetic or chemogenetic manipulation of lateral septum neurotensin neurons and their downstream connections modulates social interaction and social reward.

Claim 2interpretive mechanismsupports2022Source 1DOI PubMed

Hyperactive lateral septum neurotensin neurons in susceptible mice may cause previously rewarding social targets to be perceived as social threats, thereby occluding social reward processing.

Claim 3mechanistic associationsupports2022Source 1DOI PubMed

Stress- or threat-responsive lateral septum neurotensin neurons are activated by juvenile social interactions only in susceptible mice, not in resilient or unstressed control mice.