First-pass extracted concept

LC3

Candidate: concept label1 source documents3 linked claims

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Aliases

microtubule-associated protein 1 light chain 3

Evidence Snippets

Here we demonstrate that the rat microtubule-associated protein 1 light chain 3 (LC3) ... is associated to the autophagosome membranes after processing.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2000The EMBO JournalDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1localizationsupports2000Source 1DOI PubMed

Processed LC3 is associated with autophagosome membranes in mammalian cells.

Quoted textsource-backed

Here we demonstrate that the rat microtubule-associated protein 1 light chain 3 (LC3) ... is associated to the autophagosome membranes after processing.

Claim 2microscopy localizationsupports2000Source 1DOI PubMed

Immunoelectron microscopy showed specific LC3 labeling on autophagosome membranes in addition to cytoplasmic labeling.

Quoted textsource-backed

Immunoelectron microscopy on LC3 revealed specific labelling of autophagosome membranes in addition to the cytoplasmic labelling.

Claim 3processing mechanismsupports2000Source 1DOI PubMed

LC3-I is formed by removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by conversion of a fraction of LC3-I into LC3-II.

Quoted textsource-backed

Mutational analyses suggest that LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by the conversion of a fraction of LC3-I into LC3-II.