First-pass extracted concept

LC3-II

Candidate: concept label1 source documents5 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Evidence Snippets

Two forms of LC3, called LC3-I and -II, were produced post-translationally in various cells. LC3-II is membrane bound.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2000The EMBO JournalDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1correlationsupports2000Source 1DOI PubMed

The amount of LC3-II correlates with the extent of autophagosome formation.

Quoted textsource-backed

The amount of LC3-II is correlated with the extent of autophagosome formation.

Claim 2fraction enrichmentsupports2000Source 1DOI PubMed

LC3-II is enriched in the autophagic vacuole fraction prepared from starved rat liver.

Quoted textsource-backed

The autophagic vacuole fraction prepared from starved rat liver was enriched with LC3-II.

Claim 3molecular state distinctionsupports2000Source 1DOI PubMed

LC3-I is cytosolic whereas LC3-II is membrane bound.

Quoted textsource-backed

LC3-I is cytosolic, whereas LC3-II is membrane bound.

Claim 4novel identificationsupports2000Source 1DOI PubMed

LC3-II is the first mammalian protein identified that specifically associates with autophagosome membranes.

Quoted textsource-backed

LC3-II is the first mammalian protein identified that specifically associates with autophagosome membranes.

Claim 5processing mechanismsupports2000Source 1DOI PubMed

LC3-I is formed by removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by conversion of a fraction of LC3-I into LC3-II.

Quoted textsource-backed

Mutational analyses suggest that LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by the conversion of a fraction of LC3-I into LC3-II.