First-pass extracted concept

leader β-cells

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Ca2+ waves emanated from temporally defined leader β-cells

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019Nature MetabolismDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1analysis resultsupports2019Source 1DOI PubMed

Granger causality analysis revealed a controlling role for temporally defined leader β-cells.

Claim 2biological observationsupports2019Source 1DOI PubMed

In each in vivo setting examined, Ca2+ waves emanated from temporally defined leader β-cells and three-dimensional connectivity across the islet increased with glucose stimulation.

Claim 3causal perturbationsupports2019Source 1DOI PubMed

Photoablation of zebrafish leader cells disrupted pan-islet signalling, supporting that leader cells act as likely pacemakers.