First-pass extracted concept

left-right asymmetry of CA3-CA1 synaptic plasticity and memory processing

Candidate: concept label1 source documents3 linked claims

Jump to explainers Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Extracted Explainers

What the tool is doing

This concept refers to the paper's reported dissociation between left and right CA3 contributions to memory and synaptic potentiation. The abstract links left-origin CA3 input to CA3-CA1 LTP and left-dominant long-term memory effects.

Source 1DOI PubMed

What problem it solves

It provides the interpretive framework for why unilateral perturbation and pathway-specific plasticity measurements were performed.

Source 1DOI PubMed

Evidence Snippets

Following the induction of long-term potentiation by high-frequency electrical stimulation, synapses between CA3 and CA1 pyramidal neurons were strengthened only when presynaptic input originated in the left CA3, confirming an asymmetry in synaptic properties.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2014Proceedings of the National Academy of SciencesDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1behavioral lateralizationsupports2014Source 1DOI PubMed

Only left CA3 silencing impaired associative spatial long-term memory, whereas right CA3 silencing had no effect.

Quoted textsource-backed

only left CA3 silencing impaired performance on an associative spatial long-term memory task, whereas right CA3 silencing had no effect

Claim 2mechanistic interpretationsupports2014Source 1DOI PubMed

The dissociation of hippocampal long-term memory function between hemispheres suggests that memory is routed via distinct left-right pathways within the mouse hippocampus.

Quoted textsource-backed

The dissociation of hippocampal long-term memory function between hemispheres suggests that memory is routed via distinct left-right pathways within the mouse hippocampus

Claim 3synaptic plasticity asymmetrysupports2014Source 1DOI PubMed

CA3-CA1 synapses were strengthened after high-frequency stimulation only when presynaptic input originated in the left CA3.

Quoted textsource-backed

Following the induction of long-term potentiation by high-frequency electrical stimulation, synapses between CA3 and CA1 pyramidal neurons were strengthened only when presynaptic input originated in the left CA3