First-pass extracted concept

leucine-rich repeat

Candidate: concept label1 source documents3 linked claims

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Aliases

LRR

Evidence Snippets

The LRR is a structural module used in molecular recognition processes as diverse as cell adhesion, signal transduction, DNA repair, and RNA processing.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review1999Journal of Biological ChemistryDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1classificationsupports1999Source 1DOI PubMed

Three classes of SLRPs can be identified based on evolutionary conservation, N-terminal cysteine-rich clusters, leucine-rich repeat number, and genomic organization.

Claim 2mechanism summarysupports1999Source 1DOI PubMed

Decorin collagen-regulating activity is mediated by the protein core, likely through central LRR4-6, while glycosaminoglycan chains maintain interfibrillar spacing.

Claim 3structure functionsupports1999Source 1DOI PubMed

Leucine-rich repeats function as structural modules for molecular recognition and help explain strong protein-protein interactions in SLRPs.