First-pass extracted concept

LexA regulon

Candidate: concept label1 source documents3 linked claims

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Extracted Explainers

What the tool is doing

The LexA regulon is the set of genes repressed by LexA and induced during the SOS response. In this review it is treated as a comparative regulatory framework across bacterial species.

Source 1DOI PubMed

Resources required

The abstract points to genome-wide techniques, genetic studies, and microarray studies as the kinds of resources used to define or compare LexA regulons.

Source 1DOI PubMed

What problem it solves

It helps identify which genes are under LexA control and how SOS regulation differs across organisms.

Source 1DOI PubMed

What it does not solve

The abstract does not support a single universal LexA regulon because overlap between species is described as limited.

Source 1DOI PubMed

Alternatives

The review contrasts canonical LexA regulons with noncanonical LexA-like or LexA-paralogue-controlled gene sets in organisms such as Lactococcus lactis and Synechocystis.

Source 1DOI PubMed

Evidence Snippets

A detailed examination of LexA regulons using genome-wide techniques has recently been undertaken in both Escherichia coli and Bacillus subtilis.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2006Molecular MicrobiologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review summarysupports2006Source 1DOI PubMed

Genome-wide studies in Escherichia coli and Bacillus subtilis charted the extent of LexA regulons, uncovered new genes, and showed limited overlap between the two bacteria.

Quoted textsource-backed

These extensive and elegant studies have now charted the extent of the LexA regulons, uncovered many new genes, and exposed a limited overlap in the LexA regulon between the two bacteria.

Claim 2review summarysupports2006Source 1DOI PubMed

In Synechocystis, a LexA paralogue controls carbon-controlled genes rather than a canonical SOS gene set and is important during carbon starvation.

Quoted textsource-backed

In the cyanobacterium Synechocystis, genetic and microarray studies demonstrated that a LexA paralogue exerts control over an entirely different set of carbon-controlled genes and is crucial to cells facing carbon starvation.

Claim 3review summarysupports2006Source 1DOI PubMed

Some bacteria contain unusual LexA-related regulatory architectures, including a LexA-like protein HdiR, organisms with two lexA genes, and small DNA damage-inducible cassettes under LexA control.

Quoted textsource-backed

Several notable examples include the discovery of a LexA-like protein, HdiR, in Lactococcus lactis, organisms with two lexA genes, and small DNA damage-inducible cassettes under LexA control.