First-pass extracted concept

light-activatable GPCR effectors for vision restoration

Candidate: concept label1 source documents3 linked claims

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Aliases

G-protein coupled receptors (GPCRs)

Evidence Snippets

There are two major kinds of optogenetic effectors employed in vision restoration: ion channels and G-protein coupled receptors (GPCRs).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2018Frontiers in Cellular NeuroscienceDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1design objectivesupports2018Source 1DOI PubMed

New optogenetic tools for vision restoration are being developed to better match the broad spectral sensitivity, light sensitivity, and high temporal sensitivity of human vision.

Claim 2performance tradeoffsupports2018Source 1DOI PubMed

Light-activatable GPCRs are more light sensitive than ion channel optogenetic effectors but have slower activation and inactivation kinetics.

Claim 3therapeutic applicationsupports2018Source 1DOI PubMed

Optogenetic tools can be used therapeutically to restore vision.