LLPS is presented as the process that forms liquid-like cellular condensates and many membrane-less organelles. The review frames it as arising from interactions between proteins and nucleic acids.
First-pass extracted concept
liquid-liquid phase separation
Candidate: concept label3 source documents10 linked claims
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Aliases
biological phase separation, LLPS
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Evidence Snippets
Liquid-liquid phase separation (LLPS) is a crucial process that influences the spatial organization of cells.
Liquid-liquid phase separation (LLPS) is responsible for the emergence of intracellular membrane-less organelles and the development of coacervate protocells.
These cell condensates, typically termed liquid-like droplets, are formed by liquid-liquid phase separation (LLPS).
Supporting Sources
Linked Claims
Liquid-liquid phase separation influences the spatial organization of cells.
Physiological phase separation is connected to pathological phase transitions including conversion from a liquid to a solid state.
Dysregulation of liquid-liquid phase separation can contribute to neurodegenerative diseases, developmental disorders, and impaired immune responses.
Optically controlled LLPS systems are described as modulating biological processes including irreversible protein aggregation pathologies, transcription activation, metabolic flux, genomic rearrangements, and enzymatic reactions.
Quoted textsource-backed
In this review, recent advances in optically controlling membrane-less organelles within living organisms are summarized, thereby modulating a series of biological processes including irreversible protein aggregation pathologies, transcription activation, metabolic flux, genomic rearrangements, and enzymatic reactions.
The review presents light as an effective tool to regulate LLPS assembly dynamics and associated biochemical processes because of simplicity, precision, programmability, and noninvasiveness.
Quoted textsource-backed
Benefitting from the advantages of simplicity, precision, programmability, and noninvasiveness, light has become an effective tool to regulate the assembly dynamics of LLPS, and mediate various biochemical processes associated with LLPS.
Many membrane-less organelles are recognized as being formed by liquid-liquid phase separation caused by interactions between proteins and nucleic acids.
Quoted textsource-backed
More and more cell biologists now recognize that many of the membrane-less organelles observed in cells are formed by LLPS caused by interactions between proteins and nucleic acids.
The detailed biophysical processes within cells that lead to phase-separated assemblies remain largely unexplored.
Quoted textsource-backed
However, the detailed biophysical processes within the cell that lead to these assemblies remain largely unexplored.
Cellular liquid-like condensates are formed by liquid-liquid phase separation.
Quoted textsource-backed
These cell condensates, typically termed liquid-like droplets, are formed by liquid-liquid phase separation (LLPS).
Proper study of biological phase separation requires attention to technical issues and technical advancements.
Quoted textsource-backed
We also discuss the potential issues and technical advancements required to properly study biological phase separation.
The review covers biological phase separation in the contexts of stress granule formation, chromatin regulation, and origin-and-evolution-of-life-related processes.
Quoted textsource-backed
In this review, we evaluate recent discoveries related to biological phase separation including stress granule formation, chromatin regulation, and processes in the origin and evolution of life.