First-pass extracted concept

local GABAergic signaling within sensory ganglia

Candidate: concept label1 source documents5 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

peripheral GABAergic signaling in sensory ganglia

Evidence Snippets

Here we describe fully functional GABAergic communication within rodent peripheral sensory ganglia and show that it can modulate transmission of pain-related signals from the peripheral sensory nerves to the CNS.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2017Journal of Clinical InvestigationDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application effectsupports2017Source 1DOI PubMed

In vivo focal infusion of GABA or a GABA reuptake inhibitor to sensory ganglia reduced acute peripherally induced nociception and alleviated neuropathic and inflammatory pain.

Quoted textsource-backed

In vivo focal infusion of GABA or GABA reuptake inhibitor to sensory ganglia dramatically reduced acute peripherally induced nociception and alleviated neuropathic and inflammatory pain.

Claim 2mechanismsupports2017Source 1DOI PubMed

GABA depolarized most sensory neuron somata but still produced net inhibition of nociceptive transmission because of filtering at nociceptive fiber T-junctions.

Quoted textsource-backed

Mechanistically, GABA depolarized the majority of sensory neuron somata, yet produced a net inhibitory effect on the nociceptive transmission due to the filtering effect at nociceptive fiber T-junctions.

Claim 3mechanismsupports2017Source 1DOI PubMed

Rodent peripheral sensory ganglia contain functional GABAergic communication that modulates transmission of pain-related signals from peripheral sensory nerves to the CNS.

Quoted textsource-backed

Here we describe fully functional GABAergic communication within rodent peripheral sensory ganglia and show that it can modulate transmission of pain-related signals from the peripheral sensory nerves to the CNS.

Claim 4mechanismsupports2017Source 1DOI PubMed

Sensory neurons express major proteins necessary for GABA synthesis and release and release GABA in response to depolarization.

Quoted textsource-backed

We found that sensory neurons express major proteins necessary for GABA synthesis and release and that sensory neurons released GABA in response to depolarization.

Claim 5perturbation effectsupports2017Source 1DOI PubMed

Focal application of GABA receptor antagonists to sensory ganglia triggered or exacerbated peripherally induced nociception.

Quoted textsource-backed

In addition, focal application of GABA receptor antagonists to sensory ganglia triggered or exacerbated peripherally induced nociception.