First-pass extracted concept

locus coeruleus

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

orexin acts upstream of the amygdala via the noradrenergic locus coeruleus

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2013Proceedings of the National Academy of SciencesDOI PubMed

Linked Claims

Claim 1mechanistic pathwaysupports2013Source 1DOI PubMed

Orexin acts upstream of the amygdala via the noradrenergic locus coeruleus to enable threat learning.

Quoted textsource-backed

we show that orexin acts upstream of the amygdala via the noradrenergic locus coeruleus to enable threat (fear) learning

Claim 2mechanistic rolesupports2013Source 1DOI PubMed

The orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.

Quoted textsource-backed

Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus

Claim 3method usagesupports2013Source 1DOI PubMed

The study used behavioral pharmacology, slice physiology, and optogenetic techniques to investigate orexin-dependent threat learning circuitry.

Quoted textsource-backed

Using a combination of behavioral pharmacology, slice physiology, and optogenetic techniques