Back to first-pass browser

First-pass extracted concept

LS-projecting ventral hippocampal cells

Candidate: concept label1 source documents3 linked claims
Jump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Aliases

LS-projecting vHPC cells

Evidence Snippets

We targeted LS-projecting vHPC cells
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1anatomical distinctionsupports2017Source 1DOIPubMed

LS-projecting and mPFC-projecting ventral hippocampal cells are largely anatomically distinct cell groups.

Quoted textsource-backed
double retrograde tracing demonstrated that LS- and mPFC-projecting cells represent two largely anatomically distinct cell groups
Claim 2behavioral effectsupports2017Source 1DOIPubMed

Activation of LS-projecting ventral hippocampal cells decreased anxiety, whereas inhibition of these cells promoted anxiety.

Quoted textsource-backed
Chemogenetic manipulation of LS-projecting vHPC cells led to bidirectional changes in anxiety: activation of LS-projecting vHPC cells decreased anxiety whereas inhibition of these cells produced opposite anxiety-promoting effects.
Claim 3circuit organizationsupports2017Source 1DOIPubMed

The ventral hippocampus contains discrete projection-defined cell populations that either promote or suppress anxiety depending on their targets.

Quoted textsource-backed
our findings suggest that the vHPC houses discrete populations of cells that either promote or suppress anxiety through differences in their projection targets