First-pass extracted concept

lysine lactylation

Candidate: concept label1 source documents3 linked claims

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Aliases

global lysine lactylation, lactylation

Extracted Explainers

What the tool is doing

The abstract presents lactylation as a lactate-derived post-translational modification that links AARS1/2 to oncogenic signaling pathways in cancer.

Source 1DOI PubMed

Evidence Snippets

Lactate-derived lactylation, a post-translational modification, plays an increasingly important role in tumorigenesis.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2025Source 1DOI PubMed

AARS1 and AARS2 promote cancer proliferation through lactylation-related mechanisms.

Claim 2pathway linksupports2025Source 1DOI PubMed

Lactylation acts as a mechanistic bridge linking AARS1 and AARS2 to oncogenic signaling pathways associated with metabolic reprogramming, uncontrolled proliferation, immune escape, and therapy resistance.

Claim 3therapeutic implicationsupports2025Source 1DOI PubMed

Targeting AARS1 or AARS2 or modulating related lactylation is proposed as a potential cancer therapy strategy.