This label denotes alternatively activated macrophages in the review's framework. The abstract links M2 macrophages to Th2-associated effector functions, endocytic clearance, trophic factor synthesis, and reduced pro-inflammatory cytokine secretion.
First-pass extracted concept
M2 macrophages
Candidate: concept label2 source documents5 linked claims
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Aliases
alternatively activated macrophages, anti-inflammatory macrophages, M2, M2-like cells
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Evidence Snippets
Anti-inflammatory mediators, including IL-4, IL-10, TGF-β and M-CSF, induce diverse anti-inflammatory types of macrophages, known under the generic term M2.
Polarized macrophages can be broadly classified in two main groups... and alternatively activated macrophages (or M2), further subdivided in M2a... M2b... and M2c.
Supporting Sources
Linked Claims
Breast tumor-associated macrophages have often been propagated as anti-inflammatory M2-like cells.
Perivascular migratory TAMs are less M2-like, whereas sessile TAMs at tumor-stroma borders and/or hypoxic regions are more M2-like or trophic.
Polarized macrophages can be broadly classified into classically activated M1 and alternatively activated M2 groups.
Quoted textsource-backed
Polarized macrophages can be broadly classified in two main groups: classically activated macrophages (or M1) ... and alternatively activated macrophages (or M2)
M2 macrophages support Th2-associated effector functions and are associated with inflammation resolution, high endocytic clearance, trophic factor synthesis, and reduced pro-inflammatory cytokine secretion.
Quoted textsource-backed
M2 support Th2-associated effector functions. Beyond infection M2 polarized macrophages play a role in resolution of inflammation through high endocytic clearance capacities and trophic factor synthesis, accompanied by reduced pro-inflammatory cytokine secretion.
Alternatively activated M2 macrophages are further subdivided into M2a, M2b, and M2c subclasses associated with different inducing stimuli.
Quoted textsource-backed
alternatively activated macrophages (or M2), further subdivided in M2a (after exposure to IL-4 or IL-13), M2b (immune complexes in combination with IL-1beta or LPS) and M2c (IL-10, TGFbeta or glucocorticoids)