First-pass extracted concept

major depressive disorder

Candidate: concept label1 source documents3 linked claims

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Aliases

depression

Evidence Snippets

There is an urgent need for more effective medications to treat major depressive disorder

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2017NeurotherapeuticsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review summarysupports2017Source 1DOI PubMed

Only a minority of people exposed to prolonged stress develop stress-related psychiatric disorders including depression, while most maintain normal psychological functioning, indicating variation between susceptibility and resilience.

Quoted textsource-backed

a relatively small proportion of people (10-20%) experiencing prolonged stress develop stress-related psychiatric disorders, including depression (susceptibility to stress), whereas most stress-exposed individuals maintain normal psychological functioning (resilience to stress)

Claim 2review summarysupports2017Source 1DOI PubMed

Prolonged stressful events are an important risk factor for major depressive disorder.

Quoted textsource-backed

It is known that prolonged stressful events are an important risk factor for major depressive disorder.

Claim 3translational implicationsupports2017Source 1DOI PubMed

Pathological mechanisms of susceptibility are identified as potential therapeutic targets for depression treatment, and resilience-promoting mechanisms are reviewed as an alternative therapeutic strategy.

Quoted textsource-backed

key pathological mechanisms of susceptibility that are identified as potential therapeutic targets for depression treatment. We also review novel mechanisms that promote natural resilience as an alternative strategy to achieve treatment efficacy.