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First-pass extracted concept

MarR family proteins

Candidate: concept label1 source documents5 linked claims
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Extracted Explainers

What the tool is doing

The abstract describes MarR family proteins as bacterial repressors that regulate cellular metabolism and antibiotic resistance, with gene expression changing upon interaction with modulators.

Source 1DOIPubMed

Resources required

Not applicable from the abstract because this is a protein family concept rather than a discrete engineered tool.

Source 1DOIPubMed

What problem it solves

The review positions this family as a regulatory node for sensing modulators and controlling gene expression in bacteria.

Source 1DOIPubMed

What it does not solve

The abstract does not present MarR family proteins as a standalone toolkit item or method for engineering use.

Source 1DOIPubMed

Alternatives

The abstract mentions other proteins that detect sulfane sulfur but does not name them in the source text.

Source 1DOIPubMed

Evidence Snippets

Members of the multiple antibiotic resistance regulator (MarR) protein family are ubiquitous in bacteria and play critical roles in regulating cellular metabolism and antibiotic resistance.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1chemical mechanismsupports2024Source 1DOIPubMed

Sulfane sulfur reacts with cysteine thiols of MarR family proteins to form protein thiol persulfide, disulfide bonds, and other modifications.

Quoted textsource-backed
Sulfane sulfur reacts with the cysteine thiols of MarR family proteins, causing the formation of protein thiol persulfide, disulfide bonds, and other modifications.
Claim 2functional rolesupports2024Source 1DOIPubMed

MarR family proteins are bacterial repressors involved in regulating cellular metabolism and antibiotic resistance.

Quoted textsource-backed
Members of the multiple antibiotic resistance regulator (MarR) protein family are ubiquitous in bacteria and play critical roles in regulating cellular metabolism and antibiotic resistance. MarR family proteins function as repressors
Claim 3mechanistic overlapsupports2024Source 1DOIPubMed

Several MarR family proteins that respond to reactive oxygen species also sense sulfane sulfur because both signals induce disulfide bond formation.

Quoted textsource-backed
Several MarR family proteins that respond to reactive oxygen species (ROS) also sense sulfane sulfur, as both sulfane sulfur and ROS induce the formation of disulfide bonds.
Claim 4regulatory effectsupports2024Source 1DOIPubMed

Changing sulfane sulfur levels affect expression of many MarR-controlled genes in bacteria.

Quoted textsource-backed
Sulfane sulfur is a common cellular component in bacteria whose levels vary during bacterial growth. The changing levels of sulfane sulfur affect the expression of many MarR-controlled genes.
Claim 5sensing mechanismsupports2024Source 1DOIPubMed

Several MarR family proteins sense sulfane sulfur.

Quoted textsource-backed
recently, several MarR family proteins have been reported to sense sulfane sulfur