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matrix thalamocortical projections to layer 1 of prefrontal cortex

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Aliases

L1-projecting TC axons, matrix TC projections to L1

Evidence Snippets

Channelrhodopsin-2 was expressed in midline and paralaminar (matrix) thalamic neurons, and their L1-projecting TC axons were activated optically.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1cell type preferencesupports2012Source 1DOIPubMed

Layer 1 thalamocortical projections preferentially drive inhibitory interneurons in layer 1, especially the late-spiking subtype.

Quoted textsource-backed
L1 TC projections preferentially drove inhibitory interneurons of L1, especially those of the late-spiking subtype
Claim 2circuit effectsupports2012Source 1DOIPubMed

Layer 1 thalamocortical projections often trigger feedforward inhibition in both layer 1 interneurons and layer 2/3 pyramidal cells.

Quoted textsource-backed
and often triggered feedforward inhibition in both L1 interneurons and pyramidal cells of L2/L3
Claim 3comparative response propertysupports2012Source 1DOIPubMed

During repetitive stimulation, responses of matrix thalamocortical pathways are more sustained than responses of core sensory thalamocortical pathways.

Quoted textsource-backed
Responses during repetitive stimulation were far more sustained for matrix than for core sensory TC pathways.
Claim 4functional propertysupports2012Source 1DOIPubMed

Matrix thalamocortical projections to layer 1 of mouse prefrontal cortex can transmit relatively strong, fast, high-fidelity synaptic signals.

Quoted textsource-backed
Contrary to conventional views, we found that matrix TC projections to L1 could transmit relatively strong, fast, high-fidelity synaptic signals.
Claim 5specialization inferencesupports2012Source 1DOIPubMed

Matrix thalamocortical circuits appear specialized for robust transmission over relatively extended periods and may contribute to persistent activation relevant to working memory and state-dependent regulation of excitability.

Quoted textsource-backed
Thus, matrix TC circuits appear to be specialized for robust transmission over relatively extended periods, consistent with the sort of persistent activation observed during working memory and potentially applicable to state-dependent regulation of excitability.