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MEC-4

Candidate: concept label1 source documents4 linked claims
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Extracted Explainers

What the tool is doing

The abstract describes MEC-4 as a DEG/ENaC/ASIC ion channel required for ultrasound-evoked reversal behavior in C. elegans.

Source 1DOIPubMed

Resources required

The paper studies MEC-4 through null-mutant analysis and rescue logic involving TRP-4 overexpression.

Source 1DOIPubMed

What problem it solves

MEC-4 is presented as part of the molecular machinery that contributes to transforming ultrasound stimuli into behavior.

Source 1DOIPubMed

What it does not solve

The abstract does not establish that MEC-4 alone explains all ultrasound-evoked behavioral responses.

Source 1DOIPubMed

Alternatives

TRP-4 is presented as a cooperating mechanosensitive component rather than a simple substitute.

Source 1DOIPubMed

Evidence Snippets

a DEG/ENaC/ASIC ion channel MEC-4
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1genetic interactionsupports2022Source 1DOIPubMed

The trp-4;mec-4 double mutant shows a stronger ultrasound-evoked behavioral deficit than either single mutant.

Quoted textsource-backed
the trp-4;mec-4 double mutant shows a stronger behavioral deficit compared to either single mutant
Claim 2genetic requirementsupports2022Source 1DOIPubMed

TRP-4 and MEC-4 are both required for the ultrasound-evoked reversal response in C. elegans.

Quoted textsource-backed
TRP-4, and a DEG/ENaC/ASIC ion channel MEC-4, are both required for this ultrasound-evoked reversal response
Claim 3mechanistic requirementsupports2022Source 1DOIPubMed

At least two mechanosensitive proteins act together to generate ultrasound-evoked behavioral responses in C. elegans.

Quoted textsource-backed
we show that at least two mechanosensitive proteins act together to generate C. elegans behavioral responses to ultrasound stimuli
Claim 4rescuesupports2022Source 1DOIPubMed

Overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant.

Quoted textsource-backed
overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant