Back to first-pass browser

First-pass extracted concept

mechanosensitive ion channels

Candidate: concept label3 source documents6 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Aliases

mechanosensitive channels, MSCs

Extracted Explainers

What the tool is doing

Mechanosensitive ion channels are described as converting mechanical stimuli into electrical or chemical signals. In this review they are the candidate molecular mediators of ultrasound responses.

Source 3DOIPubMed

What problem it solves

They offer a plausible molecular basis for linking low-intensity ultrasound exposure to downstream cell signaling and therapeutic effects.

Source 3DOIPubMed

What it does not solve

The abstract does not establish that all mechanosensitive channels are ultrasound responsive, and notes that substantial evidence exists for only a limited number.

Source 3DOIPubMed

Alternatives

The abstract contrasts channel-specific mechanisms with broader physical ultrasound effects such as thermal mechanisms, cavitation, gas body activation, radiation force, acoustic streaming, and direct compressional, tensile, and shear stresses.

Source 3DOIPubMed

Evidence Snippets

Mechanistic studies revealed that mechanosensitive ion channels play a pivotal role, as their inhibition (via GdCl₃) abolished the ultrasonic effect.
Evidence 1Source 1DOIPubMedprovenance
In this review, we first discuss mechanosensitive ion channels, the most commonly utilized sonogenetic mediators, in both mammalian and non-mammalian systems.
Evidence 2Source 2DOIPubMedprovenance
Mechanosensitive channels (MSCs) play an important role in how cells transduce mechanical stimuli into electrical or chemical signals.
Evidence 3Source 3DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanism dependencysupports2025Source 1DOIPubMed

Mechanosensitive ion channels are implicated in the ultrasonic effect because GdCl3 inhibition abolished the effect.

Quoted textsource-backed
Mechanistic studies revealed that mechanosensitive ion channels play a pivotal role, as their inhibition (via GdCl₃) abolished the ultrasonic effect.
Claim 2mediator prevalencesupports2024Source 2DOIPubMed

Mechanosensitive ion channels are described as the most commonly utilized sonogenetic mediators.

Quoted textsource-backed
In this review, we first discuss mechanosensitive ion channels, the most commonly utilized sonogenetic mediators, in both mammalian and non-mammalian systems.
Claim 3usage prevalencesupports2024Source 2DOIPubMed

Mechanosensitive ion channels are described as the most commonly utilized sonogenetic mediators.

Quoted textsource-backed
In this review, we first discuss mechanosensitive ion channels, the most commonly utilized sonogenetic mediators, in both mammalian and non-mammalian systems.
Claim 4evidence scopesupports2022Source 3DOIPubMed

Only a limited number of mechanosensitive ion channels have been reported to be activated by ultrasound with substantial evidence.

Quoted textsource-backed
only a limited number of MSCs have been reported to be activated by ultrasound with substantial evidence
Claim 5mechanistic hypothesissupports2022Source 3DOIPubMed

Low-intensity ultrasound may activate specific mechanosensitive ion channels, which then trigger relevant cell signaling as a molecular mechanism for therapeutic effects.

Quoted textsource-backed
the application of low-intensity ultrasound may be associated with the activation of specific MSCs, which in turn triggers relevant cell signaling as its molecular mechanism in achieving the desired therapeutic effects
Claim 6mechanistic rolesupports2022Source 3DOIPubMed

Mechanosensitive channels transduce mechanical stimuli into electrical or chemical signals.

Quoted textsource-backed
Mechanosensitive channels (MSCs) play an important role in how cells transduce mechanical stimuli into electrical or chemical signals