medial prefrontal cortex circuitry

Optogenetics enables anatomical and functional dissection of medial prefrontal cortex circuitry with unprecedented spatial and temporal resolution.

Optogenetic methods have provided novel insights into the contribution of specific neuronal subpopulations and their connectivity to medial prefrontal cortex function in health and disease states.

The medial prefrontal cortex is critically involved in multiple cognitive functions including attention, inhibitory control, habit formation, working memory, and long-term memory.

The medial prefrontal cortex is thought to exert top-down executive control over aversive and appetitive stimulus processing through dense interconnectivity with subcortical regions including thalamus, striatum, amygdala, and hippocampus.