we next pin-pointed the medial preoptic area as a brain region strongly activated during the post-ejaculatory period
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medial preoptic area
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MPOA
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Chemogenetic activation of medial preoptic area neurons active during the post-ejaculatory period is sufficient to suppress female sexual motivation.
Quoted textsource-backed
Lastly, we found that chemogenetic activation of medial preoptic area neurons that were active during the post-ejaculatory period, but not during appetitive or consummatory periods, were sufficient to suppress female sexual motivation.
Both excitatory and inhibitory medial preoptic area neurons can increase their response to male ejaculation, but the response magnitude and proportion of responding neurons are larger in the inhibitory population.
Quoted textsource-backed
While there were excitatory and inhibitory neurons that showed increased response to male ejaculation, the response magnitude as well as the proportion of neurons responding to the event was significantly larger in the inhibitory neuron population.
A subset of medial preoptic area neurons responds significantly and specifically to male ejaculation but not to female-to-male sniffing or male mounting.
Quoted textsource-backed
we revealed that a subset of the neurons in this region responds significantly and specifically to male ejaculation but not to female-to-male sniffing or to male mounting
The medial preoptic area is strongly activated during the post-ejaculatory period.
Quoted textsource-backed
By using brain-wide analysis of activity-dependent labeling, we next pin-pointed the medial preoptic area as a brain region strongly activated during the post-ejaculatory period.
A late-responding subpopulation of medial preoptic area neurons after ejaculation is entirely inhibitory, indicating prolonged inhibitory activity in this region.
Quoted textsource-backed
we also found a subpopulation of neurons that increase their activity late after the onset of male ejaculation. These neurons were all inhibitory indicating that male ejaculation induces a prolonged inhibitory activity in the medial preoptic area.