First-pass extracted concept

melanocortin system

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

However, leptin also modulates hypothalamic neurons in an indirect manner, such as via the melanocortin system.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2014Journal of Chemical NeuroanatomyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic summarysupports2014Source 1DOI PubMed

Leptin modulates hypothalamic neurons both directly and indirectly, including through the melanocortin system.

Claim 2review summarysupports2014Source 1DOI PubMed

Leptin acts in the hypothalamus to reduce food intake and increase energy expenditure by modulating interconnected orexigenic and anorexigenic neuropeptide networks.

Claim 3review summarysupports2014Source 1DOI PubMed

The arcuate nucleus is a major leptin-sensitive hub, and leptin-responsive neurons in dorsomedial, ventromedial, paraventricular, and lateral hypothalamic regions are also direct targets of leptin.