First-pass extracted concept

metabolic reprogramming

Candidate: concept label3 source documents6 linked claims

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Extracted Explainers

What the tool is doing

Metabolic reprogramming is the review's umbrella concept for shifts in cellular metabolism associated with activation, proliferation, differentiation, inflammation, and disease. The paper compares this process across immune cells and endothelial cells.

Source 3DOI PubMed

What problem it solves

It provides a shared language for comparing how different cell compartments alter metabolism in health and pathology.

Source 3DOI PubMed

What it does not solve

By itself it does not identify a single actionable tool, and the abstract indicates that some regulator effects remain discrepant across studies.

Source 3DOI PubMed

Evidence Snippets

metabolic reprogramming

Evidence 1Source 1DOI PubMedprovenance

We discuss strategies that incorporate cytokine engineering, metabolic reprogramming, and logic-gated activation to counteract the immunosuppressive tumor microenvironment.

Evidence 2Source 2DOI PubMedprovenance

Metabolic reprogramming in immune and endothelial cells (ECs) is being studied extensively... nitric oxide, hypoxia-inducible factor, and adenosine monophosphate-activated protein kinase have been discussed for their common involvement in metabolic reprogramming of both systems.

Evidence 3Source 3DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 3review2017Frontiers in ImmunologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1engineering strategysupports2025Source 1DOI PubMed

Optimizing CARs for NK cells, integrating immune checkpoint resistance, metabolic reprogramming, and cytokine support are genetic engineering strategies intended to improve NK-cell survival and potency.

Quoted textsource-backed

We discuss the optimization of chimeric antigen receptors (CARs) specifically for NK cells, the integration of immune checkpoint resistance, metabolic reprogramming, and the incorporation of cytokine support to improve survival and potency.

Claim 2strategy rolesupports2025Source 2DOI PubMed

Cytokine engineering, metabolic reprogramming, and logic-gated activation are discussed as strategies to counteract the immunosuppressive tumor microenvironment.

Claim 3comparative review summarysupports2017Source 3DOI PubMed

Immune cells and endothelial cells can both undergo a Warburg-like metabolic switch that favors glycolysis over oxidative phosphorylation under aerobic conditions.

Claim 4disease relevance summarysupports2017Source 3DOI PubMed

Metabolic reprogramming in immune cells and endothelial cells is relevant not only in health but also in pathological states including atherosclerosis and cancer.

Claim 5evidence consistency summarymixed2017Source 3DOI PubMed

In vitro and animal studies show discrepancies regarding the effects of nitric oxide, hypoxia-inducible factor, and AMP-activated protein kinase on the metabolic switch.

Claim 6regulator involvement summarysupports2017Source 3DOI PubMed

Nitric oxide, hypoxia-inducible factor, and AMP-activated protein kinase are discussed as common regulators involved in metabolic reprogramming in both immune and endothelial systems.