First-pass extracted concept

metabotropic glutamate receptor pain modulation

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

This review will address the role of mGluRs in acute and persistent pain processing and emerging pharmacotherapies for pain management.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2019Frontiers in Molecular NeuroscienceDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1distribution summarysupports2019Source 1DOI PubMed

All mGluR subtypes except mGlu6 are expressed within nociceptive pathways where they modulate pain transmission.

Quoted textsource-backed

Of note, all mGluR subtypes (except mGlu6 receptor) are expressed within the nociceptive pathways where they modulate pain transmission.

Claim 2mechanistic summarysupports2019Source 1DOI PubMed

Metabotropic glutamate receptors are G protein-coupled receptors that modulate synaptic transmission.

Quoted textsource-backed

metabotropic glutamate receptors (mGluRs), which are G protein-coupled receptors modulating synaptic transmission

Claim 3review summarysupports2019Source 1DOI PubMed

Accumulating evidence supports glutamate receptors as promising targets for pain-relieving drug development.

Quoted textsource-backed

Over the past decades, accumulating evidence has demonstrated a pivotal role of glutamate in pain sensation and transmission, supporting glutamate receptors as promising potential targets for pain relieving drug development.