This concept groups the approaches used to observe astrocyte Ca2+ signals.
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methods to monitor astrocyte calcium signals
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Reliable methods to measure, mimic, and block specific astrocyte calcium signals with high temporal and spatial precision are needed to carefully test correlative and causative roles of these signals in astrocytes, blood vessels, neurons, and microcircuits.
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Once methods to reliably measure, mimic, and block specific astrocyte Ca(2+) signals with high temporal and spatial precision are available, researchers will be able to carefully explore the correlative and causative roles that Ca(2+) signals may play in the functions of astrocytes, blood vessels, neurons, and microcircuits in the healthy and diseased brain.
The review summarizes methods used to monitor astrocyte calcium signals, discovered signal classes, broad triggering and blocking approaches, and proposed or demonstrated physiological roles in neuronal microcircuits.
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We consider the methods that have been used to monitor astrocyte Ca(2+) signals, the various types of Ca(2+) signals that have been discovered (waves, microdomains, and intrinsic fluctuations), the approaches used to broadly trigger and block Ca(2+) signals, and, where possible, the proposed and demonstrated physiological roles for astrocyte Ca(2+) signals within neuronal microcircuits.
Studying astrocyte calcium activity in vivo is essential to distinguish pharmacological from physiological activity, and studying activity in situ is essential to rigorously explore mechanisms.
Quoted textsource-backed
Moreover, it will be essential to study astrocyte Ca(2+) activity in vivo to distinguish between pharmacological and physiological activity, and to study Ca(2+) activity in situ to rigorously explore mechanisms.