We conclude by envisioning research directions that can help in making the microfluidics-based GBA models better-suited to provide mechanistic insight into pathophysiological processes and screening therapeutics.
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microfluidics-based gut-brain axis models
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Linked Claims
Improved microfluidics-based gut-brain axis models could provide mechanistic insight into pathophysiological processes and support therapeutic screening.
Microfluidic platforms with integrated sensors and actuators can enhance in vitro gut-brain axis models by representing anatomical layout and enabling monitoring and modulation with high spatiotemporal resolution.
Use of induced pluripotent stem cells and incorporation of sensors and actuator modalities are presented as opportunities to enhance gut-brain axis microfluidic models.
Conventional in vitro models fall short of capturing gut-brain axis anatomy and physiology.
Studying gut-brain axis processes in vivo is challenging because numerous confounding factors exist.
Microfluidic technologies are useful for modeling the central nervous system, vagus nerve, gut epithelial barrier, blood-brain barrier, and their interactions in the gut-brain axis context.