First-pass extracted concept

Microphthalmia-associated transcription factor

Candidate: concept label1 source documents4 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

Mitf, MITF

Evidence Snippets

Because of limitations of space, the review focuses on the regulation of the expression and function of the Microphthalmia-associated transcription factor, Mitf.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2000Genes & DevelopmentDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1developmental originsupports2000Source 1DOI PubMed

Melanocytes originate as nonpigmented melanoblast precursors in the mouse neural crest around embryonic day 10.5 and subsequently migrate and proliferate before entering the epidermis by E13/E14.

Claim 2disease linksupports2000Source 1DOI PubMed

Recent observations link melanoma genesis to deregulation of pathways that operate in melanocyte development.

Claim 3review focussupports2000Source 1DOI PubMed

This review focuses on regulation of the expression and function of Microphthalmia-associated transcription factor in neural crest-derived melanocytes.

Claim 4uv responsesupports2000Source 1DOI PubMed

In humans, epidermal melanocytes respond to ultraviolet irradiation by increasing melanin synthesis in melanosomes that are transferred to surrounding keratinocytes as part of the tanning response.