miRNA is explicitly named as a component of combinational RNAi approaches for simultaneous silencing of multiple genes in cancer.
First-pass extracted concept
microRNA
Candidate: concept label4 source documents15 linked claims
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Aliases
miRNA, miRNAs
Extracted Explainers
What the tool is doing
What problem it solves
The abstract presents it as part of a broader multigene RNAi strategy to address resistance mechanisms in cancer cells.
The abstract supports its relevance as a mechanistic and possibly diagnostic or therapeutic topic, but does not name a discrete microRNA tool.
As a study concept, miRNA profiling is used here to assess whether postmortem depression/suicide brain tissue shows altered regulatory RNA networks.
Evidence Snippets
combinations of small interfering RNA (siRNA), microRNA (miRNA), and other small RNAs
The potential of the endocannabinoids (eCB) system, cholesterol-lowering drugs, metal chelators, and MMPs inhibitors are also explored, culminating in the exploration of the pivotal role of microRNA in AD progression.
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression.
MicroRNAs (miRNAs) are newly discovered regulators of gene expression... Expression of miRNAs was measured in prefrontal cortex (Brodmann Area 9)...
Supporting Sources
Linked Claims
Combinations of siRNA, miRNA, and other small RNAs can be used to silence multiple genes simultaneously.
The review describes microRNA as having a pivotal role in Alzheimer's disease progression.
Most miRNAs are transcribed as primary miRNAs and processed into precursor miRNAs and then mature miRNAs.
Extracellular miRNAs can be secreted into body fluids and transported via exosomes or protein association including Argonautes.
miRNA-target interactions are dynamic and depend on subcellular location, abundance of miRNAs and target mRNAs, and interaction affinity.
Under certain conditions miRNAs can activate translation or regulate transcription.
Extracellular miRNAs function as chemical messengers that mediate cell-cell communication.
miRNAs are non-coding RNAs that regulate gene expression.
In most cases miRNAs interact with 3' UTRs of target mRNAs to induce mRNA degradation and translational repression.
miRNAs have also been reported to interact with 5' UTRs, coding sequences, and gene promoters.
Twenty-one miRNAs were significantly decreased at p = 0.05 or better in prefrontal cortex of depressed suicide subjects.
Quoted textsource-backed
Using individual tests of statistical significance, 21 miRNAs were significantly decreased at p = 0.05 or better.
Widespread changes in miRNA expression are likely to participate in the pathogenesis of major depression and/or suicide.
Quoted textsource-backed
The findings show widespread changes in miRNA expression that are likely to participate in pathogenesis of major depression and/or suicide.
Overall miRNA expression was significantly and globally down-regulated in prefrontal cortex of depressed suicide subjects relative to non-psychiatric controls.
Quoted textsource-backed
Expression of miRNAs was measured in prefrontal cortex (Brodmann Area 9) of antidepressant-free depressed suicide (n = 18) and well-matched non-psychiatric control subjects (n = 17) using multiplex RT-PCR plates. We found that overall miRNA expression was significantly and globally down-regulated in prefrontal cortex of depressed suicide subjects.
Many down-regulated miRNAs were encoded at nearby chromosomal loci, shared 5'-seed motifs, and shared putative mRNA targets, several implicated in depression.
Quoted textsource-backed
Many of the down-regulated miRNAs were encoded at nearby chromosomal loci, shared motifs within the 5'-seeds, and shared putative mRNA targets, several of which have been implicated in depression.
A set of 29 miRNAs showed high co-regulation across individuals in the depressed suicide group despite lacking pairwise correlation in normal controls.
Quoted textsource-backed
In addition, a set of 29 miRNAs, whose expression was not pairwise correlated in the normal controls, showed a high degree of co-regulation across individuals in the depressed suicide group.