First-pass extracted concept

Microvillous Inclusion Disease

Candidate: concept label1 source documents6 linked claims

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Aliases

MVID

Evidence Snippets

Microvillous Inclusion Disease (MVID) is a rare congenital disorder causing severe diarrhea from early infancy, typically requiring long-term parenteral nutrition (PN).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024MEDDOI PubMed

1 evidence snippet 6 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1case observationsupports2024Source 1DOI PubMed

Amino acid-based formula did not improve the patient's condition.

Claim 2case observationsupports2024Source 1DOI PubMed

In this case, a 5-month-old male with MVID developed worsening diarrhea after switching from breast milk to polymeric formula.

Claim 3clinical implicationsupports2024Source 1DOI PubMed

This case suggests a potential risk of necrotizing enterocolitis in patients with Microvillous Inclusion Disease and supports careful management of enteral feeding.

Claim 4disease mechanismsupports2024Source 1DOI PubMed

Microvillous Inclusion Disease results from MYO5B gene mutations that disrupt brush border protein trafficking.

Claim 5rarity associationsupports2024Source 1DOI PubMed

Necrotizing enterocolitis is not typically linked to Microvillous Inclusion Disease, with only two cases reported so far.

Claim 6treatment outcomesupports2024Source 1DOI PubMed

Conservative treatment stabilized the patient's condition, and stool output improved after switching to donated breast milk.