Mitophagy degrades damaged mitochondria and supports neuronal metabolism and energy supply.
First-pass extracted concept
mitophagy
Candidate: concept label4 source documents8 linked claims
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Aliases
autophagic elimination of impaired mitochondria
Extracted Explainers
What the tool is doing
What problem it solves
It is presented as a mitochondrial quality-control process relevant to pathological changes in spinal cord ischemia-reperfusion injury.
The abstract states that elimination of dysfunctional mitochondria helps keep the immune system in check.
This mechanism addresses accumulation of damaged mitochondria in dopaminergic neurons.
What it does not solve
Evidence Snippets
mitophagy is crucial for degrading damaged mitochondria, thereby supporting neuronal metabolism and energy supply. However, while moderate mitophagy can be beneficial in the context of spinal cord ischemia-reperfusion injury, excessive mitophagy may be detrimental.
Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria.
The review title explicitly names mitophagy, and the supplied summary states the review centers on major mitophagy targeting modes.
The current article reviews the elementary role of autophagy in the degradation and elimination of superfluous and aggregated proteins and impaired mitochondria.
Supporting Sources
Linked Claims
In spinal cord ischemia-reperfusion injury, moderate mitophagy can be beneficial whereas excessive mitophagy may be detrimental.
Quoted textsource-backed
while moderate mitophagy can be beneficial in the context of spinal cord ischemia-reperfusion injury, excessive mitophagy may be detrimental
Mitophagy degrades damaged mitochondria and supports neuronal metabolism and energy supply.
Quoted textsource-backed
mitophagy is crucial for degrading damaged mitochondria, thereby supporting neuronal metabolism and energy supply
The review discusses direct and indirect evidence linking mitophagy to inflammation and autoimmunity underlying the pathogenesis of inflammatory bowel diseases, systemic lupus erythematosus, and primary biliary cirrhosis.
Quoted textsource-backed
we further discuss the direct and indirect evidence linking mitophagy to inflammation and autoimmunity underlying the pathogenesis of autoimmune diseases including inflammatory bowel diseases (IBD), systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC).
Mitophagy is a selective autophagy process that removes dysfunctional or redundant mitochondria.
Quoted textsource-backed
Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria.
Mitophagy may restrict inflammatory cytokine secretion and directly regulate mitochondrial antigen presentation and immune cell homeostasis.
Quoted textsource-backed
The process of mitophagy may restrict inflammatory cytokine secretion and directly regulate mitochondrial antigen presentation and immune cell homeostasis.
Elimination of dysfunctional mitochondria by autophagy is implicated as a means to keep the immune system in check.
Quoted textsource-backed
Accumulating evidence implicates elimination of dysfunctional mitochondria as a powerful means employed by autophagy to keep the immune system in check.
The review describes three major mitophagy targeting modes: transmembrane receptor-mediated, ubiquitin-mediated, and cardiolipin-mediated.
Autophagy degrades aggregated proteins and impaired mitochondria in nigrostriatal dopaminergic neurons, including proteins such as α-synuclein, Parkin, and ubiquitin.