However, our understanding of the LC is undergoing a dramatic shift due to the application of state-of-the-art methods that reveal a nucleus of many modules that provide targeted neuromodulation. Here, we review the evidence supporting a modular LC based on multiple levels of observation (developmental, genetic, molecular, anatomical, and neurophysiological).
First-pass extracted concept
modular locus coeruleus architecture
Candidate: concept label1 source documents3 linked claims
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Aliases
LC modularity, modular LC
Evidence Snippets
Supporting Sources
Linked Claims
The review argues that the locus coeruleus should be reconsidered as a modular, heterogeneous system rather than a singular diffuse noradrenergic nucleus.
The review states that evidence for locus coeruleus modularity spans developmental, genetic, molecular, anatomical, and neurophysiological levels of observation.
State-of-the-art methods are described as revealing that the locus coeruleus contains many modules that provide targeted neuromodulation.