First-pass extracted concept

modulation of cell-intrinsic signaling pathways

Candidate: concept label1 source documents3 linked claims

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Extracted Explainers

What the tool is doing

The review identifies modulation of cell-intrinsic signaling pathways as a major strategy for improving CAR-T performance. In the abstract, this strategy is linked to persistence and exhaustion-related bottlenecks.

Source 1DOI PubMed

What problem it solves

The abstract explicitly names poor CAR-T persistence and functional exhaustion as prominent hurdles.

Source 1DOI PubMed

Evidence Snippets

In this review, we summarize the main approaches that have been developed to face such bottlenecks, including... the modulation of cell-intrinsic signaling pathways...

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1approach summarysupports2024Source 1DOI PubMed

The review summarizes adapter CAR systems, Boolean-logic gating, epitope editing, modulation of cell-intrinsic signaling pathways, safety switches, and co-stimulatory domain selection as main approaches to address CAR-T bottlenecks.

Claim 2problem statementsupports2024Source 1DOI PubMed

Antigen escape variants, off-tumor destruction of healthy tissues expressing tumor-associated antigens, poor CAR-T cell persistence, and functional exhaustion are prominent hurdles limiting long-lasting remissions with tolerable adverse effects.

Claim 3problem statementsupports2024Source 1DOI PubMed

CAR-engineered T-cell therapy has achieved unprecedented response rates in some hematological malignancies but remains far from fulfilling its potential, especially in solid cancers.