First-pass extracted concept

modulation of transcriptional regulators, regulons, and attenuators

Candidate: concept label1 source documents3 linked claims

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Extracted Explainers

What the tool is doing

The review emphasizes rational modulation of transcriptional regulators, regulons, and attenuators as a core engineering strategy.

Source 1DOI PubMed

What problem it solves

This approach is presented as a way to rationally reprogram amino acid producing strains.

Source 1DOI PubMed

Alternatives

The abstract also highlights systems metabolic engineering tools such as sensors, CRISPR interference, small regulatory RNAs, DNA scaffolding, and optogenetic control.

Source 1DOI PubMed

Evidence Snippets

In particular, rational approaches involving modulation of transcriptional regulators, regulons, and attenuators will be discussed.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2017Bioresource TechnologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1engineering strategysupports2017Source 1DOI PubMed

Rational approaches involving modulation of transcriptional regulators, regulons, and attenuators are discussed as engineering strategies for amino acid producing strains.

Claim 2production scalesupports2017Source 1DOI PubMed

Biotechnological production of amino acids occurs at the million-ton scale, with about 6 million tons of L-glutamate and L-lysine produced annually by Escherichia coli and Corynebacterium glutamicum strains.

Claim 3review scopesupports2017Source 1DOI PubMed

The review focuses on genetic and metabolic engineering of amino acid producing strains.