First-pass extracted concept

molecular glues

Candidate: concept label2 source documents2 linked claims

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Aliases

MGs

Evidence Snippets

Molecular glues (MGs) are an emerging class of small molecules capable of inducing or enhancing protein-protein interactions

Evidence 1Source 1DOI PubMedprovenance

Targeted protein degraders, in the form of proteolysis targeting chimaeras (PROTACs) and molecular glues, leverage the ubiquitin-proteasome system to catalytically degrade specific target proteins of interest.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 0 linked claims

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1mechanistic capabilitysupports2025Source 2DOI PubMed

PROTACs and molecular glues leverage the ubiquitin-proteasome system to catalytically degrade specific target proteins.

Claim 2scope limitationsupports2025Source 2DOI PubMed

Existing targeted degrader design is largely applicable only to the same set of protein targets as traditional small molecules, approximately 15% of the human proteome.