First-pass extracted concept

mouse hind limb ischemia model

Candidate: concept label1 source documents5 linked claims

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Aliases

hind limb ischemia model

Evidence Snippets

The aim of this study was to examine whether circadian rhythm disorders would influence angiogenesis and blood perfusion recovery in a mouse model of hind limb ischemia.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2021Journal of the American Heart AssociationDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1gene expression effectsupports2021Source 1DOI PubMed

Jet-lag inhibits expression of Cry1 and Cry2 in local ischemic tissues despite ischemic injury-associated upregulation of clock genes.

Claim 2genetic perturbation effectsupports2021Source 1DOI PubMed

Cry1 and Cry2 double-knockout mice show reduced capillary density and reduced blood perfusion recovery in hind limb ischemia.

Claim 3mechanistic associationsupports2021Source 1DOI PubMed

The impaired angiogenesis and perfusion recovery under jet-lag are associated with downregulation of VEGF expression in local ischemic tissue and plasma.

Claim 4overall conclusionsupports2021Source 1DOI PubMed

Circadian rhythm disorder deteriorates reparative ischemia-induced angiogenesis, and maintenance of circadian rhythm is important for angiogenesis.

Claim 5phenotypic effectsupports2021Source 1DOI PubMed

Jet-lag condition impairs reparative angiogenesis and blood perfusion recovery in mouse hind limb ischemia.