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mPFC-projecting ventral hippocampal cells

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Aliases

mPFC-projecting vHPC cells

Evidence Snippets

We targeted LS-projecting vHPC cells and mPFC-projecting vHPC cells
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1anatomical distinctionsupports2017Source 1DOIPubMed

LS-projecting and mPFC-projecting ventral hippocampal cells are largely anatomically distinct cell groups.

Quoted textsource-backed
double retrograde tracing demonstrated that LS- and mPFC-projecting cells represent two largely anatomically distinct cell groups
Claim 2behavioral effectsupports2017Source 1DOIPubMed

mPFC-projecting ventral hippocampal cells promoted anxiety.

Quoted textsource-backed
The observed anxiety-reducing function of LS-projecting cells was in contrast with the function of mPFC-projecting cells, which promoted anxiety.
Claim 3circuit organizationsupports2017Source 1DOIPubMed

The ventral hippocampus contains discrete projection-defined cell populations that either promote or suppress anxiety depending on their targets.

Quoted textsource-backed
our findings suggest that the vHPC houses discrete populations of cells that either promote or suppress anxiety through differences in their projection targets