First-pass extracted concept

mushroom body α'/β' neurons

Candidate: concept label1 source documents3 linked claims

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Aliases

MB α'/β' neurons

Evidence Snippets

DPMs increase sleep via release of GABA onto wake-promoting mushroom body (MB) α'/β' neurons.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2015eLifeDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1assay resultsupports2015Source 1DOI PubMed

Functional imaging showed that DPM activation evokes robust chloride increases in mushroom body neurons but no detectable calcium or cAMP increases.

Claim 2mechanismsupports2015Source 1DOI PubMed

DPM neurons increase sleep by releasing GABA onto wake-promoting mushroom body α'/β' neurons.

Claim 3perturbation effectsupports2015Source 1DOI PubMed

Downregulation of α'/β' GABAA and GABABR3 receptors causes sleep loss, supporting these receptors as sleep-relevant targets of DPM-mediated inhibition.