We conclude that future studies need to analyze activity-driven adaptations to both axons and their myelin sheaths to fully understand how myelinated axon plasticity contributes to neuronal circuit formation and function.
First-pass extracted concept
myelinated axon plasticity
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Fine-tuning of conduction along already-myelinated axons may be mediated by alterations to the axon itself.
Quoted textsource-backed
Finally, we propose that precise fine-tuning of conduction along already-myelinated axons may also be mediated by alterations to the axon itself.
Neuronal activity can rapidly tune axonal diameter and can promote oligodendrocyte progenitor cell cycle re-entry or direct differentiation into oligodendrocytes.
Quoted textsource-backed
We highlight the observations that neuronal activity can rapidly tune axonal diameter, promote re-entry of oligodendrocyte progenitor cells into the cell cycle, or drive their direct differentiation into oligodendrocytes.
White matter and myelinated axons can be dynamically regulated by activity in the healthy brain.
Quoted textsource-backed
MRI-based imaging studies have shown that white matter, primarily composed of myelinated axons, can also be dynamically regulated by activity of the healthy brain.