First-pass extracted concept

myofilament Ca2+ sensitivity

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Another possibility is the change of Ca2+ sensitivity of the contractile apparatus.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review1989HypertensionDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic summarysupports1989Source 1DOI PubMed

During the sustained phase of agonist-induced contraction, intracellular Ca2+ concentration is reported to be lower than during high K+ stimulation or in chemically skinned smooth muscle preparations, implying that a second regulatory system may exist.

Claim 2mechanistic summarymixed1989Source 1DOI PubMed

Recent literature on phorbol ester-induced vasoconstriction tends to support a role for protein kinase C in changing Ca2+ sensitivity of contractile proteins, but a clear link between receptors, protein kinase C, and myofilaments is not established.

Claim 3method enabled mechanistic claimsupports1989Source 1DOI PubMed

Using permeabilized smooth muscle fibers that retain receptor and signal transduction function, activation of G protein by norepinephrine or GTP-gamma-S enhances myofilament sensitivity to Ca2+.